In previous posts, we’ve established the role of saturated fats in elevating LDL cholesterol as well as the causal role of elevated LDL cholesterol in heart disease, contradicting false claims made by a number of journalists, bloggers, YouTubers, and crank doctors that have tried to confuse the public regarding the relationship between saturated fats, LDL cholesterol, and heart disease. Using GPT-4o, we now explore the precise mechanisms by which saturated fats in the diet elevate LDL cholesterol.

A number of journalists, bloggers, YouTubers, and crank doctors have tried to confuse the public regarding the relationship between LDL cholesterol and heart disease. Mendelian randomization is another method to investigate the relationship between LDL cholesterol and heart disease. Here we use GPT-4o to explain Mendelian randomization and to look at the evidence from Mendelian randomization for LDL cholesterol playing a causal role in heart disease.

In my last post, “What Causes Heart Disease?,” we saw that the most rigorous scientific evidence still supports the fact that elevated LDL cholesterol is the primary driver of heart disease — despite the fact that some profit-motivated journalists, bloggers, and YouTubers claim otherwise.

With so much confusion, controversy, and deliberate deception surrounding the primary causes of heart disease, I decided to put the question to four AI models.